Formulasi dan Karakterisasi Etosom Fikosianin

Abstrak

Phycocyanin is a blue pigment from Spirulina platensis that has strong antioxidant activity and has the potential to be used in topical preparations, but its absorption is limited due to its hydrophilic nature. To increase skin penetration, ficocyanin is formulated in an ethosome-based delivery system. This study aims to formulate and characterize ficocyanine ethosomes as a topical preparation. Ethosomes were prepared in 3 formulas namely F1, F2, and F3, by the cold method using varying concentrations of ethanol (20, 30, and 40%) and phosphatidylcholine (2, 3, and 4%). Phycocyanin ethosomes were then characterized, including organoleptic, pH, vesicle morphology using an optical microscope, sorption efficiency with UV-Vis spectrophotometer, particle size and polydispersity index with Particle Size Analyzer, and zeta potential using zetasizer. The results showed that all formulas had a blue color, liquid form, characteristic odor, and round-shaped vesicles. The pH values ranged from 6.41 to 6.49. Phycocyanin sorption efficiency was in the range of 58.74 to 86.77%. The optimum formula (F3) showed a particle size of 276.05 nm, a polydispersity index of 0.38, and a zeta potential value of +1.35 mV. Thus, phycosianin ethosomes are potentially to be developed for topical preparation as an antioxidant.

Kata kunci

• Antioksidan
• Fikosianin
• Spirulina platensis
• etosom